Table 5.

Associations between the identified CpGs and classical cardiovascular risk factors (CVRFs) in the fixed-effects meta-analyses of the four samples

CpG	Smoking	BMI*	HDL-C*	LDL-C*	TG*	Glucose	SBP	DBP*
cg21566642	− 1.61	9.55 × 10–3	7.69 × 10–4	− 1.10 × 10–3	− 4.17 × 10–4	2.32 × 10–4	2.30 × 10–3	7.97 × 10–3	Coefficient
	4.22 × 10–2	2.65 × 10–3	1.21 × 10–3	4.09 × 10–4	1.95 × 10–4	4.20 × 10–4	9.02 × 10–4	1.67 × 10–3	SE*
	< 2.2 × 10–16	3.21 × 10–4	5.24 × 10–1	7.11 × 10–3	3.22 × 10–2	5.81 × 10–1	1.08 × 10–2	1.78 × 10–6	P
cg05575921	− 1.61	1.17 × 10–2	4.36 × 10–3	− 1.35 × 10–3	− 7.09 × 10–4	1.86 × 10–4	2.15 × 10–3	7.54 × 10–3	Coefficient
	4.22 × 10–2	2.46 × 10–3	1.11 × 10–3	3.77 × 10–4	1.79 × 10–4	3.87 × 10–4	8.23 × 10–4	1.52 × 10–3	SE*
	< 2.2 × 10–16	2.22 × 10–6	8.22 × 10–5	3.39 × 10–4	7.63 × 10–5	6.30 × 10–1	9.06 × 10–3	7.69 × 10–7	P
cg25769469	− 9.01 × 10–2	− 1.12 × 10–2	6.76 × 10–3	2.47 × 10–4	− 1.38 × 10–3	− 1.52 × 10–3	− 2.35 × 10–3	− 4.17 × 10–3	Coefficient
	5.08 × 10–2	2.64 × 10–3	1.20 × 10–3	4.11 × 10–4	1.93 × 10–4	4.17 × 10–4	9.10 × 10–4	1.69 × 10–3	SE*
	7.65 × 10–2	2.32 × 10–5	1.92 × 10–8	5.48 × 10–1	8.75 × 10–13	2.69 × 10–4	9.97 × 10–3	1.36 × 10–2	P
cg04988978	− 7.29 × 10–2	− 1.15 × 10–2	5.28 × 10–3	3.59 × 10–4	− 1.19 × 10–3	− 1.88 × 10–3	− 2.88 × 10–3	− 3.54 × 10–3	Coefficient
	5.15 × 10–2	2.64 × 10–3	1.20 × 10–3	4.08 × 10–4	1.92 × 10–4	4.15 × 10–4	9.02 × 10–4	1.67 × 10–3	SE*
	1.57 × 10–1	1.26 × 10–5	1.08 × 10–5	3.80 × 10–1	5.79 × 10–10	5.97 × 10–6	1.41 × 10–3	3.47 × 10–2	P

*BMI, Body mass index; HDL-C, Cholesterol in high-density lipoprotein; LDL-C, Cholesterol in low-density lipoprotein; TG, Triglycerides; SBP, Systolic blood pressure; DBP, Diastolic blood pressure; SE, Standard Error