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. 2021 Apr 21;20:80. doi: 10.1186/s12933-021-01270-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Sacubitril/valsartan (sac/val) ameliorates in vivo aortic stiffening, as well as endothelial stiffening in ex vivo aortic explants. a Pulse wave velocity (PWV) measured after 10 weeks of treatment. N = 6, 5, 5, and 7 for ZOC, ZOSV, ZOV and ZOH, respectively. b Force measurements were acquired by interaction between a cantilever tip and the EC surface of aortic explants from rats after 10 weeks of treatment. N = 4, 4, 4, 5 and 3 for ZOC, ZOSV, ZOV and ZOH, respectively. c Sac/val (▼) and val (○) treatments prevent impaired responses to the nitric oxide dependent vasodilator, acetylcholine in aortic rings of ZO rats (○). Note the normal reactivity of in ZLC aortae (●). Data are represented by means ± SE in the accompanying bar graph. N = 3, 8, 8, 7 and 7 for ZLC, ZOC, ZOSV, ZOV and ZOH, respectively. Symbols: *Indicates p < 0.05 versus ZLC; ^†Indicates p < 0.05 versus ZOC; indicates ^§p < 0.05 versus ZOH