Table 4.
Summary of cytokine profile changes in Zucker Obese (ZO) rats treated with sacubitril/valsartan (ZOSV), valsartan (ZOV), and hydralazine (ZOH) when compared to control rats (ZOC)
| Molecule | Gene | ZOSV /ZOC | ZOV/ZOC | ZOH/ZOC | |||
|---|---|---|---|---|---|---|---|
| log2FC | P-value | log2FC | P-value | log2FC | P-value | ||
| Neuropilin-1 | Nrp1 | − 0.266 | 0.001 | − 0.398 | 0.005 | − 0.173 | 0.052 |
| Notch1 | Notch1 | − 0.768 | 0.003 | − 1.108 | 0.002 | − 0.976 | 0.002 |
| PDGF-AA | Pdgfa | 1.054 | 0.041 | ||||
| L-Selectin | Sell | 0.800 | 0.044 | ||||
| IFNg | Ifng | 0.550 | 0.020 | ||||
| IL-4 | Il4 | 0.386 | 2.61E-05 | ||||
| JAM-A | F11r | -− 0.271 | 0.021 | − 0.317 | 0.010 | ||
| RANTES | Ccl5 | − 0.436 | 0.014 | ||||
| Flt-3L | Flt3l | − 0.464 | 0.047 | ||||
| IL-17F | Il17f | − 0.668 | 0.037 | ||||
| Galectin-3 | Lgals3 | − 0.572 | 0.044 | ||||
Notch Notch receptor 1, IFN Interferon, JAM-A Junctional Adhesion Molecule A, Flt-3L FMS related Receptor Tyrosine Kinase 3 Ligand
Molecules on the cytokine array that showed at least log2 fold-change (log2FC) of 1.2 and with a p-value ≤ 0.05 are shown. Statistical significance between the indicated groups determined by unpaired two-tailed t-tests. Gene symbols corresponding to each cytokine are shown. Sample size: N = 4/group