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. 2021 Apr 22;22:146. doi: 10.1186/s12882-021-02358-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Non-Necrotizing Granulomatous Interstitial Nephritis. a Granulomatous interstitial nephritis with interstitial infiltration by mononuclear cells and noncaseating granulomas with multinucleated giant cells (arrows) (hematoxylin and eosin and PAS, both original magnification × 200), with negative Ziehl-Neelsen and Grocott stains (not shown). We performed immunohistochemistry for CD45, CD3 (b), CD4, CD8, CD20, CD68, CD138 and CD31. The interstitium is affected by a mixed cellular inflammatory infiltrate. CD3 T lymphocytes are the most represented elements, with CD4 and CD8 positive subpopulation, B lymphocytes in minority part, various plasma cells, histiocytes, plurinuclear giant cells and some granulocytes neutrophils