Table 1.

Main clinical studies reporting renal histology in Inflammatory Bowel Disease

References	N	Renal Histology	Comments
Ambruzs et al. [12]	45 CD 38 UC	24% IgA Nephropathy; 19%Interstitial Nephritis; 12% Nephrosclerosis; 8% Acute Tubular Injury; 7% Proliferative GN; 4% Minimal change disease;	• Prevalence of IgAN significantly higher in patients with IBD than in healthy population • Association with HLA-DR1described in both IBD and IgAN • All patients with interstitial nephritis were previously exposed to aminosalicylates
Jang et al. [13]	7 CD	5 IgA Nephropathy; 1 Henoch-Schönlein purpura; 1 No alterations;
Archimandritis et al. [14]	1 CD	Interstitial nephritis with granulomas	• Full recovery after proctocolectomy
Izzedine et al. [15]	4 CD	4 Interstitial Nephritis	• All diagnosed before administration of mesalazina • Progression to end-stage renal failure in 3 patients • Granulomas were identified in 2 patients
Hubert et al. [16]	1 CD 1 UC	IgA Nephropathy	• Restoration of renal findingsafter treatment for IBD
Ridder et al. [17]	1 UC	Membranous Nephropathy	• Presentation with intestinal manifestation • Improvement after therapy
Pohjonen et al. [18]	14 CD 14 UC 7 UND	7 IgA Nephropathy; 2 Membranous Nephropathy; 2 IgM GN; 4 acute interstitial nephritis; 4 chronic interstitial nephritis;	• All patients with interstitial nephropathy had an history of mesalazina administration
Ota et al. [19]	1 CD	acute tubulointerstitial nephritis	• After the discontinuation of IFX, renal abnormalities resolved

CD Chron disease, GN glomerulonephrities, IBD inflammatory bowel disease, UC ulcerative colitis, UND undetermined