Table 5.
Results of sensitivity analyses for the association between depressive symptom categories, diagnosed sleep disorders and heart disease
| Adjusted model | |
|---|---|
| HR (95% CI) | |
| Sensitivity analyses for sleep disorders | |
| Analysis 1: diagnosed sleep disorders in the 5 years prior to baseline survey | |
| No/low depressive symptoms and sleep disorder | 1.37 (1.13–1.65) |
| Elevated depressive symptoms and no sleep disorder | 1.38 (1.22–1.55) |
| Elevated depressive symptoms and sleep disorder | 2.42 (1.86–3.15) |
| Analysis 2: excluding sleep item from PHQ-9 | |
| No/low depressive symptoms and sleep disorder | 1.39 (1.09–1.77) |
| Elevated depressive symptoms and no sleep disorder | 1.37 (1.20–1.57) |
| Elevated depressive symptoms and sleep disorder | 2.67 (1.77–4.00) |
| Analysis 3: using PHQ-9 cut-off score of ⩾10 | |
| No/low depressive symptoms and sleep disorder | 1.43 (1.14–1.79) |
| Elevated depressive symptoms and no sleep disorder | 1.36 (1.13–1.64) |
| Elevated depressive symptoms and sleep disorder | 2.92 (1.72–4.95) |
| Analysis 4: competing-risk regression accounting for mortality | |
| No/low depressive symptoms and sleep disorder | 1.33 (1.02–1.73) |
| Elevated depressive symptoms and no sleep disorder | 1.38 (1.23–1.55) |
| Elevated depressive symptoms and sleep disorder | 2.55 (1.79–3.65) |
| Sensitivity analyses for sleep duration | |
| Analysis 5: excluding sleep item from PHQ-9 | |
| Normal sleep duration and no/low depressive symptoms | Reference |
| Normal sleep duration and elevated depressive symptoms | 1.47 (1.24–1.73) |
| Short sleep (⩽6 h) and no/low depressive symptoms | 1.15 (1.02–1.28) |
| Short sleep (⩽6 h) and elevated depressive symptoms | 1.23 (0.96–1.56) |
| Long sleep (⩾9 h) and no/low depressive symptoms | 1.19 (1.02–1.38) |
| Long sleep (⩾9 h) and elevated depressive symptoms | 1.67 (1.25–2.22) |
| Analysis 6: using PHQ-9 cut-off score of ⩾10 | |
| Normal sleep duration and no/low depressive symptoms | Reference |
| Normal sleep duration and elevated depressive symptoms | 1.50 (1.17–1.94) |
| Short sleep (⩽6 h) and no/low depressive symptoms | 1.12 (1.04–1.38) |
| Short sleep (⩽6 h) and elevated depressive symptoms | 1.20 (0.88–1.63) |
| Long sleep (⩾9 h) and no/low depressive symptoms | 1.19 (1.04–1.38) |
| Long sleep (⩾9 h) and elevated depressive symptoms | 1.64 (1.11–2.42) |
| Analysis 7: competing-risk regression accounting for mortality | |
| Normal sleep duration and no/low depressive symptoms | Reference |
| Normal sleep duration and elevated depressive symptoms | 1.41 (1.22–1.64) |
| Short sleep (⩽6 h) and no/low depressive symptoms | 1.12 (0.99–1.26) |
| Short sleep (⩽6 h) and elevated depressive symptoms | 1.34 (1.11–1.62) |
| Long sleep (⩾9 h) and no/low depressive symptoms | 1.16 (0.99–1.36) |
| Long sleep (⩾9 h) and elevated depressive symptoms | 1.71 (1.32–2.22) |
All models are adjusted for the following variables: age, sex, education, ethnicity, smoking status, alcohol consumption, physical activity, cholesterol, diagnoses diabetes and diagnosed high blood pressure.