Figure 1.

1‐locus 2‐drive TARE. (a) In the 1‐locus 2‐drive system, two TARE drive alleles (a and b) are situated at the same locus. Each targets a different essential but haplosufficient gene while providing rescue for the other drive allele's target. (b) The time at which a TARE‐based drive with a GE promoter is expected to reach 99% of individuals in the population in our simulation model with varying drive‐carrying individual introduction frequency and drive fitness. Released individuals have one copy of each drive allele at the drive site. Gray indicates that the drive was eliminated within 100 generations