Figure 2.

2‐locus drives. (a) In the 2‐locus drive systems, two drive alleles (both providing “same‐site” rescue in this example) each target an essential but haplosufficient gene while providing rescue for the other drive allele's target. (b) The time at which a 2‐locus drive with unlinked, same‐site TARE alleles with a GE promoter is expected to reach 99% of individuals in the population with varying introduction frequency and drive fitness. (c) The introduction frequency thresholds for TARE drives with additional loci, where each drive cyclically provides rescue for the target of the previous drive. (d) As in (b), but for TADDE alleles. (e) As in (b), but for TADE alleles with a germline (G) promoter. (f) As in (b), but for TADE alleles with a promoter causing cutting activity in the germline of both sexes and in embryos of drive‐carrying females (GE). Released individuals are homozygous for all drive alleles. Gray indicates that the drive was eliminated within 100 generations