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. Author manuscript; available in PMC: 2021 Apr 22.
Published in final edited form as: DNA Repair (Amst). 2019 Dec 5;86:102767. doi: 10.1016/j.dnarep.2019.102767

Fig. 8.

Fig. 8.

Models of 8oxoG long-patch BER in each Domain of life. 8oxo BER is initiated by a DNA glycosylase (Ogg1, AGOG or Fpg). In Eukarya and Archaea, downstream repair is carried out by an AP endonuclease (APE1 or EndoIV), DNA polymerase, Fen1 and DNA ligase. In Bacteria, downstream repair requires ExoIII or EndoIV, Pol I, and DNA ligase.