TABLE 2.

Adjusted Odds Ratio for Primary Outcome Risk Factors

Exposure	Adjusted Odds Ratio (95% CI)*
	KP	RKOA	TKR
Age (yr)	0.99 (0.98-1.00)†	1.08 (1.05-1.10)†	1.09 (1.07-1.11)†
BMI (kg/m2)
Normal	Reference	Reference	Reference
Overweight	1.50 (1.13-2.01)†	0.92 (0.55-1.54)	1.50 (0.90-2.50)
Obese	2.28 (1.55-3.33)†	1.18 (0.59-2.36)	2.03 (1.11-3.73)‡
Pattern 3 digit ratio	1.34 (1.05-1.72)‡	0.92 (0.59-1.44)	1.33 (0.86-2.05)
Nodal OA	1.21 (0.77-1.92)	0.81 (0.29-2.30)	2.24 (1.28-3.90)†
Familial OA	1.51 (1.17-1.94)†	1.49 (0.99-2.26)	1.16 (0.76-1.77)
Suffers from gout	2.16 (1.46-3.20)†	2.71 (1.13-6.49)‡	1.76 (1.09-2.86)‡
Constitutional malalignment	1.28 (0.93-1.76)	1.15 (0.66-1.99)	2.04 (1.25-3.33)†
High-risk occupation	1.19 (0.94-1.51)	1.00 (0.66-1.51)	0.90 (0.61-1.33)
Knee injury	4.22 (3.26-5.48)†	2.88 (1.81-4.59)†	4.83 (2.87-8.13)†
Career training dose (per 1000 h)	1.00 (0.97-1.03)	1.07 (1.01-1.12)‡	0.98 (0.95-1.05)
Matches played (per 100 matches)	0.96 (0.91-1.00)	1.06 (0.97-1.15)	0.91 (0.83-0.99)‡
Main tier§
One	0.97 (0.75-1.25)	0.81 (0.52-1.27)	1.11 (0.74-1.67)
Two	1.07 (0.80-1.42)	1.10 (0.86-1.40)	1.03 (0.64-1.67)
Three	1.09 (0.81-1.47)	1.05 (0.89-1.25)	0.91 (0.55-1.53)
Four	0.88 (0.60-1.30)	0.96 (0.82-1.12)	0.72 (0.32-1.63)
Position¶
Goalkeeper	1.33 (0.89-1.98)	1.14 (0.58-2.24)	0.87 (0.45-1.68)
Defender	0.86 (0.68-1.11)	1.12 (0.90-1.39)	1.27 (0.84-1.92)
Midfielder	1.00 (0.77-1.29)	1.07 (0.91-1.24)	0.78 (0.49-1.23)
Forward	1.05 (0.81-1.35)	0.88 (0.78-0.98)‡	1.03 (0.69-1.56)

This table reports the aORs (adjusted for age and BMI), and 95% CIs of all potential risk factors for all 3 KOA outcomes, namely KP, RKOA, and TKR.

^*Odds ratios adjusted for age and BMI.

^†P < 0.01.

^‡P < 0.05.

^§Adjusted OR presented with respect to all other tiers.

^¶Adjusted OR presented with respect to all other positions.