Figure 10.

FoxP1 expression is increased in skeletal muscle of patients with pancreatic ductal adenocarcinoma (PDAC) exhibiting cachexia. (A–B) FOXP1 protein expression is increased in rectus abdominis muscle biopsies from cachectic PDAC patients compared with non‐cancer control patients. In panel (A), arrows point to the two FoxP1 isoforms quantified in B. (C–E) FOXP1 mRNA expression in rectus abdominis muscle of PDAC patients correlates positively with body mass loss (C) and negatively with skeletal muscle index (D) and is increased in cachectic PDAC patients when compared with weight‐stable non‐cancer controls with normal muscularity (E). Note: mRNA data were extracted from microarray analyses previously analysed and published in combination with histological assessment of muscle biopsies ²⁰ and in combination with MRI‐based measures of skeletal muscularity and muscle quality. ⁶⁸ Statistical differences were determined by conducting unpaired two‐tailed t‐test or Mann–Whitney tests depending on data distribution in panels (B) and (E), and simple linear regression analyses in panels (C) and (D). Data are reported as mean ± SEM.