Table 6.
Details of shared pHLAs; 3-year dnDSA-positive cases in the shared TE-positive group (n = 7).
| Pt | DnDSA | Presenting HLA loci | Presented shared peptide | The origin of shared peptide | |||
|---|---|---|---|---|---|---|---|
| No. | Pre-sensitizing HLA | Donor HLA | |||||
| 1 | DQB1*06:04 | DRB1*14:06 | ITQRKWEAARVAEQL | B*54:01 | A*33:03, B*44:03 | ||
| DRB1*14:06 | QRKWEAARVAEQLRA | B*54:01 | A*33:03, B*44:03 | ||||
| DRB1*14:06 | QLRAYLEGTCVEWLR | B*54:01 | A*33:03 | ||||
| DRB1*14:06 | RAYLEGTCVEWLRRY | B*54:01 | A*33:03 | ||||
| DQA1*05:03 DQB1*03:01 | QLRAYLEGTCVEWLR | B*54:01 | A*33:03 | ||||
| DQA1*05:03 DQB1*03:01 | AQITQRKWEAARVAE | B*54:01 | A*33:03, B*44:03 | ||||
| DQA1*05:03 DQB1*03:01 | QRKWEAARVAEQLRA | B*54:01 | A*33:03, B*44:03 | ||||
| 5 | DRB3*03:01, | DQA1*01:03 DQB1*06:01 | AQITQRKWEAARVAE | B*37:01 | A*33:03, B*44:03 | ||
| DRB4*01:03 | |||||||
| 7 | DQB1*03:01 | DRB1*13:02 | SMRYFYTSVSRPGRG | A*26:01 | A*02:06 | ||
| DRB1*13:02 | SHSMRYFYTSVSRPG | A*26:01 | A*02:06 | ||||
| DRB1*13:02 | HSMRYFYTSVSRPGR | A*26:01 | A*02:06 | ||||
| DRB1*15:02 | SMRYFYTSVSRPGRG | A*26:01 | A*02:06 | ||||
| DRB1*15:02 | SHSMRYFYTSVSRPG | A*26:01 | A*02:06 | ||||
| DRB3*03:01 | SHSMRYFYTSVSRPG | A*26:01 | A*02:06 | ||||
| DRB3*03:01 | MRYFYTSVSRPGRGE | A*26:01 | A*02:06 | ||||
| DRB3*03:01 | HSMRYFYTSVSRPGR | A*26:01 | A*02:06 | ||||
| DRB5*01:02 | AVVAAVMWRRKSSDR | A*26:01 | A*02:06 | ||||
| DRB5*01:02 | YTSVSRPGRGEPRFI | A*26:01 | A*02:06 | ||||
| DRB5*01:02 | KETLQRTDAPKTHMT | A*26:01 | A*02:06 | ||||
| DRB5*01:02 | SMRYFYTSVSRPGRG | A*26:01 | A*02:06 | ||||
| DRB5*01:02 | MRYFYTSVSRPGRGE | A*26:01 | A*02:06 | ||||
| DQA1*01:02 DQB1*06:04 | SHSMRYFYTSVSRPG | A*26:01 | A*02:06 | ||||
| DQA1*01:03 DQB1*06:01 | SHSMRYFYTSVSRPG | A*26:01 | A*02:06 | ||||
| DQA1*01:03 DQB1*06:01 | SMRYFYTSVSRPGRG | A*26:01 | A*02:06 | ||||
| DQA1*01:03 DQB1*06:04 | SHSMRYFYTSVSRPG | A*26:01 | A*02:06 | ||||
| 8 | DRB4*01:03 | DRB1*01:01 | DIVADHVASYGVNLY | DQA1*05:01 | DQA1*03:02 | ||
| DRB1*01:01 | EDIVADHVASYGVNL | DQA1*05:01 | DQA1*03:02 | ||||
| DRB1*01:01 | FDPQFALTNIAVLKH | DQA1*05:01 | DQA1*03:02 | ||||
| DRB1*01:01 | ASYGVNLYQSYGPSG | DQA1*05:01 | DQA1*03:02 | ||||
| DRB1*01:01 | VVNITWLSNGHSVTE | DQA1*05:01 | DQA1*03:02 | ||||
| DRB1*01:01 | VADHVASYGVNLYQS | DQA1*05:01 | DQA1*03:02 | ||||
| DRB1*15:02 | QFALTNIAVLKHNLN | DQA1*05:01 | DQA1*03:02 | ||||
| DRB1*15:02 | PVVNITWLSNGHSVT | DQA1*05:01 | DQA1*03:02 | ||||
| DRB1*15:02 | FDPQFALTNIAVLKH | DQA1*05:01 | DQA1*03:02 | ||||
| DRB1*15:02 | PQFALTNIAVLKHNL | DQA1*05:01 | DQA1*03:02 | ||||
| DRB1*15:02 | ADHVASYGVNLYQSY | DQA1*05:01 | DQA1*03:02 | ||||
| DRB5*01:02 | QFALTNIAVLKHNLN | DQA1*05:01 | DQA1*03:02 | ||||
| DRB5*01:02 | VVNITWLSNGHSVTE | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:01 DQB1*06:01 | ITWLSNGHSVTEGVS | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:01 DQB1*06:01 | TWLSNGHSVTEGVSE | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:01 DQB1*06:01 | RSNSTAATNEVPEVT | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:01 DQB1*06:01 | ADHVASYGVNLYQSY | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:01 DQB1*06:01 | PQFALTNIAVLKHNL | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:01 DQB1*06:01 | KRSNSTAATNEVPEV | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:01 DQB1*06:01 | FDPQFALTNIAVLKH | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:01 DQB1*06:01 | QFALTNIAVLKHNLN | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:01 DQB1*06:01 | DIVADHVASYGVNLY | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*05:01 | ADHVASYGVNLYQSY | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*05:01 | VASYGVNLYQSYGPS | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | NITWLSNGHSVTEGV | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | IVADHVASYGVNLYQ | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | VNITWLSNGHSVTEG | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | TWLSNGHSVTEGVSE | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | ADHVASYGVNLYQSY | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | FDPQFALTNIAVLKH | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | PQFALTNIAVLKHNL | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | ITWLSNGHSVTEGVS | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | WLSNGHSVTEGVSET | DQA1*05:01 | DQA1*03:02 | ||||
| DQA1*01:03 DQB1*06:01 | DIVADHVASYGVNLY | DQA1*05:01 | DQA1*03:02 | ||||
| 29 | A*01:01 | DQA1*03:02 DQB1*03:03 | ALNEDLRSWTAADMA | A*34:01 | A*01:01 | ||
| DQA1*05:03 DQB1*03:03 | IALNEDLRSWTAADM | A*34:01 | A*01:01 | ||||
| DRB1*09:01 | DTYCRHNYGVVESFT | DRB1*15:01 | DRB1*04:03 | ||||
| DQA1*03:02 DQB1*03:01 | YCRHNYGVVESFTVQ | DRB1*15:01 | DRB1*04:03 | ||||
| DQA1*05:03 DQB1*03:01 | YCRHNYGVVESFTVQ | DRB1*15:01 | DRB1*04:03 | ||||
| DQA1*05:03 DQB1*03:03 | YCRHNYGVVESFTVQ | DRB1*15:01 | DRB1*04:03 | ||||
| 38 | DRB1*04:01 | DRB1*15:01 | EVTVYPAKTQPLQHH | DRB1*09:01 | DRB1*04:01 | ||
| DRB5*01:01 | EVTVYPAKTQPLQHH | DRB1*09:01 | DRB1*04:01 | ||||
| DQA1*01:02 DQB1*06:02 | RNGQEEKAGVVSTGL | DRB1*09:01 | DRB4*01:02 | ||||
| 40 | DRB5*01:01, | DRB1*08:03 | RFDPQFALTNIAVLK | DQA1*05:05 | DQA1*03:03 | ||
| DQA1*03:03 | DRB1*08:03 | HVASYGVNLYQSYGP | DQA1*05:05 | DQA1*03:03 | |||
| DRB1*08:03 | NITWLSNGHSVTEGV | DQA1*05:05 | DQA1*03:03 | ||||
| DRB1*08:03 | DIVADHVASYGVNLY | DQA1*05:05 | DQA1*03:03 | ||||
| DRB1*08:03 | IKRSNSTAATNEVPE | DQA1*05:05 | DQA1*03:03 | ||||
| DRB1*08:03 | QFALTNIAVLKHNLN | DQA1*05:05 | DQA1*03:03 | ||||
| DRB1*08:03 | PVVNITWLSNGHSVT | DQA1*05:05 | DQA1*03:03 | ||||
| DRB1*08:03 | ADHVASYGVNLYQSY | DQA1*05:05 | DQA1*03:03 | ||||
| DRB1*13:02 | VVNITWLSNGHSVTE | DQA1*05:05 | DQA1*03:03 | ||||
| DRB1*13:02 | EDIVADHVASYGVNL | DQA1*05:05 | DQA1*03:03 | ||||
| DRB1*13:02 | QFALTNIAVLKHNLN | DQA1*05:05 | DQA1*03:03 | ||||
| DRB3*03:01 | QFALTNIAVLKHNLN | DQA1*05:05 | DQA1*03:03 | ||||
| DRB3*03:01 | RFDPQFALTNIAVLK | DQA1*05:05 | DQA1*03:03 | ||||
| DRB3*03:01 | PVVNITWLSNGHSVT | DQA1*05:05 | DQA1*03:03 | ||||
| DRB3*03:01 | EDIVADHVASYGVNL | DQA1*05:05 | DQA1*03:03 | ||||
| DRB3*03:01 | ADHVASYGVNLYQSY | DQA1*05:05 | DQA1*03:03 | ||||
| DRB3*03:01 | VASYGVNLYQSYGPS | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | NITWLSNGHSVTEGV | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | IVADHVASYGVNLYQ | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | VNITWLSNGHSVTEG | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | TWLSNGHSVTEGVSE | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | ADHVASYGVNLYQSY | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | FDPQFALTNIAVLKH | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | PQFALTNIAVLKHNL | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | ITWLSNGHSVTEGVS | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | WLSNGHSVTEGVSET | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:01 | DIVADHVASYGVNLY | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:04 | IVADHVASYGVNLYQ | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:04 | EDIVADHVASYGVNL | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:03 DQB1*06:04 | ADHVASYGVNLYQSY | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | PVVNITWLSNGHSVT | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | NITWLSNGHSVTEGV | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | IVADHVASYGVNLYQ | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | RSNSTAATNEVPEVT | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | DPQFALTNIAVLKHN | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | ITWLSNGHSVTEGVS | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | ADHVASYGVNLYQSY | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | KRSNSTAATNEVPEV | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | FDPQFALTNIAVLKH | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | PQFALTNIAVLKHNL | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | WLSNGHSVTEGVSET | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:01 | DIVADHVASYGVNLY | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:04 | FDPQFALTNIAVLKH | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:04 | IVADHVASYGVNLYQ | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:04 | EDIVADHVASYGVNL | DQA1*05:05 | DQA1*03:03 | ||||
| DQA1*01:02 DQB1*06:04 | ADHVASYGVNLYQSY | DQA1*05:05 | DQA1*03:03 | ||||
dnDSA, de novo donor-specific anti-HLA antibodies; Pt, patient; pHLA, peptide in the context of recipient HLA class II; No., number; A, alanine; R, arginine; N, asparagine; D, aspartic acid; C, cysteine; Q, glutamine; E, glutamic acid; G, glycine; H, histidine; I, Isoleucine; L, leucine; K, lysine; M, methionine; F, phenylalanine; P, proline; S, serine; T, threonine; W, Tryptophan; Y, tyrosine; V, valine.