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. Author manuscript; available in PMC: 2021 Jul 15.
Published in final edited form as: Sci Transl Med. 2020 Jul 15;12(552):eaaz7287. doi: 10.1126/scitranslmed.aaz7287

Fig. 6. Effects of M3mP6 in a mouse artery perforation model of surgical bleeding and dog buccal mucosal bleeding time (BMBT) test.

Fig. 6.

(A) Illustration of a mouse surgical bleeding model. (B) Comparison of M3mP6 HLPN (10 μmol/kg, n=20) with high dose cangrelor (30 μg/kg, n=16), high dose cangrelor plus M3mP6 HLPN (n=17), low dose cangrelor (10 μg/kg, n=11)), low dose cangrelor plus M3mP6 HLPN (n=12) and normal control (n=27) in the artery perforation model of surgical bleeding. (C) BMBT test of the effect of M3mP6 HLPN on hemostasis in dogs (n=3) ****P<0.0001, n.s.: not significant; Mann-Whitney test in (B), unpaired t-test in (C); data presented as means ± SEM.