Table 2.
Pharmacokinetic profile of systemically administered drugs used for PKDL[60]
| Amphotericin B | Miltefosine | Paromomycin | Antimonials | |
|---|---|---|---|---|
| Route of administration | IV | Oral | IM | IM/IV |
| Accumulation | Liver, spleen | Not reported | Not reported | Liver, thyroid, heart |
| Distribution in skin | Not reported (confirmed in rats) | Not reported (confirmed in rats) | Not reported | Confirmed |
| Metabolism | Reticuloendothelial system engulfs liposomes containing Amp B | Metabolized by Phospholipase D intracellularly | Not metabolized | Converted to Sb3+ intracellularly |
| Elimination | Urine and feces | Not excreted unchanged | Urine | Urine |