Table 2.
Multivariable logistic regression model for any mortality or morbidity adjusted for total parenteral nutrition and age at NBS collection.
| Variable | Any Morbidity or Mortality | No Morbidity or Mortality | Parameter Estimate (Std Error) | OR (95% CI) | Standardized Estimate |
|---|---|---|---|---|---|
| Female | 2,667 (41.65) | 28,951 (45.57) | −0.31 (0.04) | 0.74 (0.68–0.80) | −0.084 |
| C-Section | 3,823 (59.70) | 19,316 (30.40) | 0.58 (0.04) | 1.79 (1.66–1.93) | 0.151 |
| Race/Ethnicity | |||||
| White non-Hispanic | 1,366 (21.33) | 12,932 (20.35) | Ref | Ref | Ref |
| Asian | 816 (12.74) | 9,425 (14.83) | −0.35 (0.06) | 0.71 (0.62–0.80) | −0.068 |
| Black | 389 (6.07) | 2,724 (4.29) | −0.13 (0.09) | 0.87 (0.73–1.05) | −0.015 |
| Hispanic | 3,357 (52.42) | 34,429 (54.19) | −0.18 (0.05) | 0.83 (0.75–0.92) | −0.051 |
| Other | 476 (7.43) | 4,024 (6.33) | −0.12 (0.09) | 0.89 (0.75–1.05) | −0.017 |
| Education (years) | |||||
| <12 | 1884 (29.42) | 20,605 (32.43) | −0.22 (0.05) | 0.80 (0.73–0.89) | −0.057 |
| High School | 1,486 (23.20) | 14,427 (22.71) | −0.15 (0.05) | 0.87 (0.78–0.96) | −0.034 |
| >12 | 2,714 (42.38) | 26,224 (41.28) | Ref | Ref | Ref |
| Unknown | 320 (5.00) | 2,278 (3.59) | −0.02 (0.10) | 0.98 (0.81–1.19) | −0.002 |
| Birthweight (per 100g) | 17.9 (8.10) | 28.3 (5.20) | −0.06 (0.01) | 0.94 (0.93–0.95) | −0.216 |
| Gestational age (weeks) | 31.3 (3.70) | 35.3 (1.20) | −0.29 (0.01) | 0.75 (0.73–0.77) | −0.311 |
| 17 Hydroxyprogesterone | 4.27 (0.90) | 3.33 (0.65) | 0.47 (0.03) | 1.61 (1.52–1.70) | 0.191 |
| TSH | 0.74 (0.96) | 1.47 (0.61) | −0.48 (0.04) | 0.62 (0.59–0.65) | −0.179 |
| GALT | 5.43 (0.28) | 5.50 (0.23) | −0.47 (0.08) | 0.63 (0.53–0.74) | −0.060 |
| 5-Oxoproline | 3.37 (0.61) | 3.54 (0.55) | −0.12 (0.03) | 0.89 (0.83–0.95) | −0.037 |
| Glycine | 6.29 (0.33) | 6.35 (0.28) | 0.41 (0.09 | 1.51 (1.27–1.78) | 0.064 |
| Leucine/Isoleucine | 4.94 (0.49) | 4.65 (0.28) | −0.54 (0.11) | 0.59 (0.48–0.72) | −0.093 |
| Ornithine | 4.69 (0.52) | 4.58 (0.35) | −1.01 (0.07) | 0.36 (0.32–0.42) | −0.205 |
| Phenylalanine | 4.37 (0.32) | 4.15 (0.23) | 2.42 (0.11) | 11.19 (9.03–13.87) | 0.330 |
| Proline | 5.24 (0.49) | 5.19 (0.34) | 0.31 (0.07) | 1.37 (1.19–1.57) | 0.062 |
| Tyrosine | 4.54 (0.65) | 4.66 (0.42) | −0.64 (0.04) | 0.53 (0.49–0.57) | −0.159 |
| C-2 | 3.17 (0.37) | 3.20 (0.31) | −0.71 (0.08) | 0.49 (0.42–0.58) | −0.121 |
| C-3 | 0.89 (0.43) | 0.69 (0.40) | 0.35 (0.06) | 1.42 (1.26–1.60) | 0.078 |
| C-4 | −1.01 (0.51) | −1.33 (0.50) | 0.29 (0.05) | 1.33 (1.22–1.45) | 0.081 |
| C-5 | −1.37 (0.61) | −1.97 (0.54) | 0.25 (0.05) | 1.29 (1.17–1.41) | 0.079 |
| C-10 | −3.06 (0.78) | −2.48 (0.66) | −0.13 (0.03) | 0.87 (0.83–0.92) | −0.051 |
| C-12 | −2.43 (0.75) | −1.80 (0.57) | −0.38 (0.03) | 0.68 (0.64–0.73) | −0.130 |
| C-12:1 | −3.24 (0.85) | −2.59 (0.83) | −0.10 (0.03) | 0.90 (0.86–0.95) | −0.048 |
| C-16:1 | −1.77 (0.52) | −1.53 (0.46) | 0.25 (0.05) | 1.28 (1.17–1.42) | 0.064 |
| C-18:2 | −1.34 (0.63) | −1.60 (0.51) | −0.23 (0.04) | 0.80 (0.74–0.86) | −0.066 |
All metabolites are natural log transformed. Original units – umol/L
GALT: galactose-1-phosphate uridyl transferase; TSH: thyroid stimulating hormone; OR: Odds Ratio; CI: confidence interval.
All variables have model p-value of <0.001
Continuous variables described using mean and SD and ORs by per unit increase. Categorical variables described using frequencies and proportions. T-tests and χ2 tests for continuous and categorical variables respectively