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. Author manuscript; available in PMC: 2021 Apr 22.
Published in final edited form as: ACS Chem Biol. 2019 Jul 25;14(8):1698–1707. doi: 10.1021/acschembio.9b00079

Figure 2. Initial analysis of vinyl nucleoside incorporation into RNA.

Figure 2.

A. Crystal structures of uridine-cytidine kinase and adenosine kinase bound to cytidine and adenosine, respectively. PDB: 1UEI, 1BX4 B. Structures of vinyl-nucleosides C. Incorporation levels of vinyl-nucleosides. HEK293T cells were treated for 12 h at 1 mM final concentration, after which RNA was isolated. Percent incorporation was determined through total RNA digestion and LC-MS/MS analysis of mono-nucleoside mixtures.