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. Author manuscript; available in PMC: 2021 Apr 22.
Published in final edited form as: ACS Chem Biol. 2019 Jul 25;14(8):1698–1707. doi: 10.1021/acschembio.9b00079

Figure 3. Screening tetrazines for IEDDA reactions with vinyl nucleosides.

Figure 3.

A. Structures of tetrazines synthesized for this study. B. Comparison between HOMO-LUMO+1 energy gap and IEDDA rate constants. Second- order rate constants were determined from reactions containing 1 mM tetrazine and 10, 12.5, 15, 17.5 and 20 mM vinyl nucleoside or nucleobase.