Table 2.
Sepsis Resuscitation and Organ Failure Severity.a
| Overall,b N = l7l | Gram negative, n = 67 | Gram positive, n = 46 | Culture negative, n = 47 | P value | |
|---|---|---|---|---|---|
| Initial SOFA score (first 24 hours) | 6 (4–10) | 6 (4–10) | 8 (5–10) | 4 (3–7) | .0001c |
| 48-hour SOFA score | 4 (1–7) | 4.5 (2–7) | 5 (1– 8) | 2 (1–6) | .0848c |
| Lactate (mmol/L) | 3 (2.2–4.6) | 3.0 (2.4–4.8) | 3.15 (2.1–4.6) | 2.6 (2.0–4.0) | .1952c |
| Mechanical ventilationd | 69 (40.6) | 22 (33.3) | 26 (56.5) | 15 (31.9) | .021e |
| Time from ED triage to antibiotics (minutes) | 113 (77–175) | 127 (84–187) | 102.5 (75–144) | 108 (75–167) | .2452c |
| Fluids in first 6 hours (mL) | 3000 (2000–4000) | 3000 (2000–4200) | 3000 (2000–4000) | 2750 (1000–4000) | .4556c |
| Fluids in first 24 hours (mL) | 4000 (3000–6000) | 5000 (3000–7000) | 4625 (2350–6050) | 4000 (3000–5750) | .4168c |
| Septic shockd | 84 (49.4) | 37 (56.1) | 28 (60.9) | 15 (31.9) | .010e |
| Mortalityd | 46 (27.1) | 18 (26.9) | 15 (33.3) | 11 (23.4) | .557e |
| Septic shock mortalityd | 35 (42.2) | 14 (37.8) | 12 (44.4) | 7 (46.7) | .794e |
Abbreviations: ED, emergency department; IQR, interquartile range; SOFA, Sequential Organ Failure Assessment Score.
a
Data are median and (IQR), unless otherwise specified.
b
Eleven patients with mixed growth cultures excluded from between group analyses.
c
Kruskal-Wallis.
d
Count and (%).
e
χ2.