Table 1.

Top 5 genes from a gene-based segregation test (GESE) of 34 rare variants in 14 genes under the linkage peak

Gene	Rare variants/ segregating rare variants, n	Observed probability	p value	Weighted p value
NRBF2	1/1	0.00015	0.00051	0.00538
PCDH15	10/2	0.00017	0.00774	0.00220
ASAH2*	1/1	0.00141	0.01275	0.00408
ANK3	5/1	0.00454	0.04415	0.01403
JMJD1C	7/2	0.02067	0.24728	0.09346

The number of rare variants per gene relative to the number of rare variants segregating with bipolar disorder status across the 15 families with bipolar disorder (n = 117 individuals). The observed segregating probability for each gene is provided, as is the basic gene-based p value for association after simulations and the genebased p value after per-family weight corrections. Suggestive p values (< 0.1) are reported.

^*Genes not expressed in the brain (defined by reads per kilobase per million [RPKM] < 1 in developmental transcriptomics RNA sequence data, representing 65% of mapped genes).