Table 1.
Laboratory measures
| Variable | Reference range | Pneumonia | Vaccination | |||
|---|---|---|---|---|---|---|
|
|
|
|||||
| 3 months previous | 3 days prior | 4 days after | 5 days after | 6 days after | ||
| Leukocyte count, × 109/L | 4.0–11.0 | 8.4 | 5.7 | 11.1 | 6.3 | — |
| Neutrophils, × 109/L | 2.0–8.0 | 6.3 | 2.7 | 9.1 | 4.3 | — |
| Monocytes, × 109/L | 0.1–0.8 | 0.7 | 0.5 | 0.9 | 0.6 | — |
| Lymphocytes, × 109/L | 1.0–4.0 | 1.3 | 2.3 | 1.1 | 1.5 | — |
| High-sensitivity CRP, mg/L | ≤ 7.5‡ | 65.6§ | — | 160.1 | 101.6 | 32.5 |
| Clozapine dose, mg/d | 500 | 300 | 300 | 0 | 0 | |
| Clozapine, nM/L (US ng/mL) | 1070 (350)¶ | 3984 (1302) | 1630 (533) | 3296 (1078) | 1212 (396) | |
| Norclozapine, nM/L (US ng/mL) | 1343 (439) | 586 (192) | 880 (288) | 773 (253) | ||
| C/N* | ≤ 2 | 2.95 | 2.78 | 3.75 | 1.57 | |
| C/D† | 0.6–1.2 | 2.6 | 1.8 | 3.6 | 2.2 | |
CRP = C-reactive protein.
*
Ratio of clozapine to norclozapine level, value > 2 indicates slow metabolism.
†
Ratio of clozapine level in ng/mL to clozapine dose in mg; requires a steady state or mean of 5 previous days used, a higher value indicates lower clearance.
‡
Higher value indicates active inflammation or infection.
§
Previous baseline 4.1; recovered in 6 days to 5.8.
¶
Therapeutic level.