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. 2021 Mar 16;10(6):1231. doi: 10.3390/jcm10061231

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MPO-ANCA GN associates with interstitial vasculitis and inflammation, interstitial fibrosis and tubular atrophy. (A) Representative periodic acid-Schiff and Masson-Goldner-stained kidney sections of MPO-ANCA and PR3-ANCA GN are shown (scale bars: 200 μm). (B) Association between MPO-ANCA compared to PR3-ANCA GN with regard of tubulointerstitial findings analogous to the Banff scoring system are shown by heatmap reflecting mean values of Spearman’s ρ, asterisks (*) indicate p < 0.05. ah, arteriolar hyalinosis; ANCA, antineutrophil cytoplasmic antibodies; ci, interstitial fibrosis; ct, tubular atrophy; g, glomerulitis; GN, glomerulonephritis; i, interstitial inflammation; i-IFTA, inflammation in IFTA; IQR, interquartile range; MPO, myeloperoxidase; PR3, proteinase 3; t, tubulitis; ptc, peritubular capillaritis; ti, total inflammation; t-IFTA, tubulitis in IFTA; v, arteritis.