Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 22;433(13):167003. doi: 10.1016/j.jmb.2021.167003

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Elsevier Ltd. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Comparison of SARS-CoV and SARS-CoV-2 M^pro structures with GC373 drug. (A). Overall 3-dimensional structures show similarities between SARS-CoV M^pro (wheat) and SARS CoV-2 M^pro (cyan) with an RMSD of 0.6 Å. GC373 binds covalently with the catalytic Cys145 of the M^pro of both SARS-CoV (7LCP.pdb) and SARS-CoV-2 (6TWK.pdb) and shows (B) similar oxyanion hole coordination by Ser144, Gly143 and Asn142 and (C) drug adduct coordination with side chains of His163, Glu166 and backbone of Phe140.