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. 2021 Apr 22;433(13):167003. doi: 10.1016/j.jmb.2021.167003

Figure 8.

Figure 8

The N-terminal finger of the Mpro stabilizes dimer formation and coordination of the drug GC373. The N-finger of Mpro facilitates coordination of drug GC373 in both in SARS- CoV (7LCQ.PDB) (A) and SARS-CoV-2 (6WTJ.PDB) (B). Overall the 3-dimensional structures show the N terminus (red) inserts into the second protomer in SARS-CoV Mpro (wheat) and in SARS-CoV-2 Mpro (cyan). Both residues that coordinate the N-finger, Phe140 and Glu166 also interact with the P1 position of the drug in Mpro of both SARS-CoV and SARS-CoV-2.