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. 2021 Apr 20;9(1):e002104. doi: 10.1136/bmjdrc-2020-002104

Figure 2.

Figure 2

Effects of ICV infusion of dapagliflozin and empagliflozin on food intake and water intake. 0.52 µmol or 4.16 µmol (high-dose)/3 µL of dapagliflozin, 0.52 µmol/3 µL of empagliflozin or 3 µL of vehicle was infused into the LV of rats, and food and water intake were measured at 0, 1.5, 3, 6, and 24 hours after ICV infusion. (A) Cumulative food intake after ICV 0.52 µmol dapagliflozin administration. (B) Cumulative food intake after ICV 0.52 µmol empagliflozin administration. (C) Cumulative food intake. (D) Cumulative water intake after high-dose dapagliflozin administration. (E) Daily food and (F) water intake from 2 days before to 6 days after high-dose dapagliflozin administration. (A–D) Data are presented as the mean±SD. (E, F) Data are presented as the mean±SEM. Significance relative to vehicle control: *p<0.05, **p<0.01. V: vehicle, D: dapagliflozin, E: empagliflozin, HD: high-dose dapagliflozin A (V, D): n=13 and 13, respectively. B (V, E): n=14 and 14, respectively. C–F (V, HD) n=7 and 8, respectively. ICV, intracerebroventricular administration; LV, lateral ventricle.