Table 3.

Relationships between haemodynamic parameters and incidence of non-fatal and fatal first-time coronary events and the significance of difference between the two different outcomes

	Non-fatal coronary event			Fatal coronary event			Heterogeneity
	HR	95% CI	P value	HR	95% CI	P value	P value
Orthostatic hypotension
Model 1	1.29	1.14 to 1.45	<0.001	1.32	1.10 to 1.58	0.003	0.84
Model 2	1.09	0.96 to 1.23	0.180	1.02	0.84 to 1.23	0.860	0.56
∆SBP per −10∆mm Hg
Model 1	1.10	1.06 to 1.14	<0.001	1.07	1.01 to 1.14	0.015	0.52
Model 2	1.03	1.00 to 1.07	0.084	0.97	0.92 to 1.03	0.364	0.089
∆DBP per −10∆mm Hg
Model 1	1.16	1.09 to 1.23	<0.001	1.10	1.00 to 1.21	0.041	0.37
Model 2*	1.06	1.00 to 1.13	0.058	0.95	0.86 to 1.04	0.275	0.052
PP per 10 mm Hg
Model 1	1.13	1.10 to 1.17	<0.001	1.22	1.17 to 1.27	<0.001	0.007
Model 2†	1.10	1.07 to 1.13	<0.001	1.18	1.13 to 1.23	<0.001	0.013
RHR per 10 bpm
Model 1	1.07	1.03 to 1.10	<0.001	1.22	1.17 to 1.28	<0.001	<0.0001
Model 2	0.98	0.95 to 1.01	0.181	1.09	1.04 to 1.15	0.001	0.0004

Model 1 includes covariates age and gender.

Model 2 includes age, gender, diabetes, smoking habits, cholesterol, body mass index, antihypertensive treatment and systolic blood pressure.

*Adjusted for diastolic instead of systolic blood pressure.

†Not adjusted for systolic or diastolic blood pressure.

bpm, beats per minute; DBP, diastolic blood pressure; PP, pulse pressure; RHR, resting heart rate at baseline; SBP, systolic blood pressure.