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. 2021 Apr 21;9(4):e001955. doi: 10.1136/jitc-2020-001955

Figure 5.

Figure 5

Tumor growth delay effect with the addition of DC agonist is dependent on CD8 T cells, T cells’ ability to egress from the lymph nodes, but is not enhanced with the addition of TLR agonist (A) experimental procedure for RT, anti-CD25, anti-CD137, anti-CD4, and anti-CD8 treatment in the MOC2 tumor model. (B) Tumor growth curves for mice treated with RT+anti-CD25+anti-CD137 alone or with anti-CD4, anti-CD8 or anti-CD4+anti-CD8 in the MOC2 tumor model and replicate values for all mice alive on day 21 postimplantation (n=13 mice/group on day 0, one-way ANOVA with Tukey test). (C) Experimental procedure for RT, anti-CD25, anti-CD137, anti-PD-L1, and FTY720 treatment in the MOC2 tumor model. (D) Tumor growth curves for mice treated with RT, RT+anti-CD25, RT+anti-CD25+anti-CD137, RT+anti-CD25+anti-CD137+anti-PD-L1 or RT+anti-CD25+anti-CD137+anti-PD-L1+FTY720 in the MOC2 tumor model and replicate values for all mice alive on day 34 post-implantation (n=8 mice/group on day 0, one-way ANOVA with Tukey test). (E) Experimental procedure for RT, anti-CD25, anti-CD137, and Poly:IC treatment in the MOC2 tumor model. (F) Tumor growth curves for mice treated with RT, RT+anti-CD25+anti-CD137, or RT+anti-CD25+anti-CD137+Poly:IC in the MOC2 tumor model. Tumor volumes bar chart for all mice alive on day 14 post-implantation (n=9 mice/group on day 0, one-way ANOVA with Tukey test). ANOVA, analysis of variance; RT, radiation therapy; TLR, toll-like receptor.