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. 2021 Apr 20;9(4):e002460. doi: 10.1136/jitc-2021-002460

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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IL-6 signaling in intratumoral macrophages is required for full vaccine-induced tumor regression. Tumor outgrowth graphs also indicating the number of alive mice from the total tested above the x-axis (A, B), the average tumor outgrowth (C; mean values with SEM), and the response rate according to RECIST criteria (D; NR, no response; PR, partial response; CR, complete response) of Il6ra^fl/fl×LysM^cre+, Il6ra^fl/fl×LysM^cre- and wild-type mice treated with SLP vaccine or kept untreated. Data are pooled from three independent experiments. (E) The percentage of intratumoral CD8⁺ cells within live gate (left) and the percentage of E7 Tm⁺ cells within CD8⁺ cells of Il6ra^fl/fl×LysM^cre+, Il6ra^fl/fl×LysM^cre- SLP vaccinated mice. Graphs indicate mean values with SEM each dot represents data from an individual mouse. Data are representative of one experiment. Significance was determined by unpaired Student’s t-test for difference in endpoint tumor size (day 22) in (C) and Mann-Whitney U test in (E), within each tumor model. *P<0.05; **p<0.01. IL-6, interleukin 6; SLP, synthetic long peptide.