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Small intestinal multi-scale features shown on native tissue (A–C) are imprinted into negative Parylene molds (D–F) used for solution casting of positive PDMS replicas (G–I) as biomimetic growth substrates. A,D,G bar = 1 mm; B,E,H bar = 500 μM; C,F,I bar = 200 μM, * denotes villus structure, arrow denotes crypt.
