Table 4:

The mean normalized abundance of genera of Firmicutes in Pre-OMM control-period fecal samples (95% CI) compared to Post-OMM (95% CI) with p-values of within-subject repeated measures ANOVA. The effect sizes (Cohen’s d) of the change in normalized abundance of genera post-OMM were calculated.

Genera (n = 6)	Mean Normalized Abundance			Significant pre-OMM correlations (rho, p-value)
	Pre-OMM (95% CI)	Post-OMM (95% CI) p-value	Effect Size (d)
Roseburia (Family Lachnospiraceae)	24,255 (11589, 36921)	50,369 (17806, 82931) .033*	1.109	• Hoehn and Yahr (rs = −.883, p = .020) • Mobility, Gait, and Posture composite score (rs = −.829, p = .042) • 3.3 (rs = −.886, p = .019) • 4.6 (rs = −.956, p = .003) • Part 3 and 4.6 (rs = −.899, p = .015)
Intestimonas (Family Unclassified Clostridiales)	2,567 (322, 4811)	1,443 (18, 2868) .035*	0.627	• Total UPDRS (rs = .829, p = .042) • Hoehn and Yahr (rs = .971, p = .001) • 3.10 (rs = .926, p = .008) • 3.13 (rs = .841, p = .036) • Mobility, Gait, & Posture composite score (rs = .886, p = .019) • 4.6 (rs = .837, p = .038) • Part 3 and 4.6 (rs = .928, p = .008)

Cohen’s d categories: 0.2 = small, 0.5 = moderate, 0.8 = large. The significant, non-parametric, two-tailed Spearman’s rho correlations of Pre-OMM genera to UPDRS,

^*p ≤ 0.05.

Measure of PD severity quantified by each UPDRS subscale: Part 3 Motor Examination; 3.3 Rigidity; 3.10 Gait; 3.13 Posture; Part 4: Motor Complications; 4.6 Painful Off-State Dystonia.

Abbreviations: UPDRS: Unified PD Rating Scale.