Fig. 1.

Associations among fat mass, CRP, and working memory over time without theorized mediational pathways (A), and mediation model testing indirect associations in links between fat mass, CRP, and working memory over time (B). In examining Pathway 1, the link between adiposity at age 9 and working memory at age 10 was statistically mediated by CRP at age 9, as hypothesized. Similarly, in Pathway 2, the link between working memory at age 10 and CRP at age 15.5 was statistically mediated by adiposity at age 15.5, again as hypothesized. When adjusting for covariates (see main text), both mediations remained significant. Autoregressive paths are grayed out for ease of viewing the primary paths of interest. All coefficients are standardized (β) coefficients.