Table 1.
Participant characteristics overall and stratified by SLCO1B1 T/T versus C-carrier genotypes
| Characteristic | All (n = 379) |
SLCO1B1 T/T (n = 259; 68%) |
SCLO1B1 C/T or C/C (n = 120; 32%) |
ap-value |
|---|---|---|---|---|
| Male sex | 193* (51%) | 138 (53%) | 55 (46%) | 0.166 |
| Age started atorvastatin (years) | 56.9 ± 10.8 | 56.9 ± 10.8 | 57.0 ± 10.9 | 0.940 |
| Atorvastatin dose (mg) | 22.3 ± 18.0 | 22.7 ± 18.4 | 21.6 ± 17.2 | 0.588 |
| Coronary artery disease | 77 (20%) | 58 (22%) | 19 (16%) | 0.140 |
| Myocardial infarction | 55 (15%) | 39 (15%) | 16 (13%) | 0.658 |
| Hypertension | 181 (48%) | 119 (46%) | 62 (52%) | 0.300 |
| Smoker | 115 (30%) | 78 (30%) | 37 (31%) | 0.888 |
| Family history of heart disease | 171 (45%) | 126 (49%) | 45 (38%) | 0.043 |
| Hypothyroidism | 42 (11%) | 27 (10%) | 15 (13%) | 0.549 |
| Heavy alcohol consumption | 5 (1.3%) | 4 (1.5%) | 1 (0.8%) | 1.000 |
| Obesity | 64 (17%) | 44 (17%) | 20 (17%) | 0.938 |
| Kidney disease | 9 (2.4%) | 6 (2.3%) | 3 (2.5%) | 1.000 |
| Diabetes | 59 (16%) | 42 (16%) | 17 (14%) | 0.609 |
| Family history of muscle disease | 27 (7.1%) | 14 (5.4%) | 13 (11%) | 0.056 |
| Metabolic muscle disease | 10 (2.6%) | 7 (2.7%) | 3 (2.5%) | 1.000 |
| Inflammatory muscle disease | 26 (6.9%) | 20 (7.7%) | 6 (5%) | 0.330 |
| Liver disease | 10 (2.6%) | 7 (2.7%) | 3 (2.5%) | 1.000 |
| Discontinued atorvastatin due to SAMS | 233 (61%) | 158 (61%) | 75 (63%) | 0.781 |
| Discontinued atorvastatin due to elevated CK | 55 (15%) | 38 (15%) | 17 (14%) | 0.897 |
a
Continuous variables are presented as mean ± standard deviation and compared between the two SLCO1B1 genotype groups by the student’s t-test. Categorical variables are presented as counts (%) and compared between the two SLCO1B1 genotype groups with the chi-square or Fisher’s exact test where necessary. Bolded values are for p < 0.05.
*
Sex was undisclosed for one participant.
CK = creatine kinase; SAMS = statin-associated muscle symptoms; SLCO1B1 = solute carrier organic anion transporter family member 1B1