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. 2021 Apr 22;16(4):e0250356. doi: 10.1371/journal.pone.0250356

Table 3. Clinical practice guidelines using a systematic or non-systematic approach to evidence syntheses (n = 50).

Type of evidence synthesis Guidelines n (%*)
Reviews: 47 (94%)
Non-systematic reviews 31 (62%)
  • with qualitative synthesis 22 (44%)
  • with pairwise meta-analysis 7 (14%)
  • with network meta-analyses 2 (4%)
Systematic reviews 16 (32%)
  • with qualitative synthesis 11 (22%)
  • with pairwise meta-analysis 3 (6%)
  • with network meta-analyses 2 (4%)
Overviews: 3 (6%)
Non-systematic overviews 2 (4%)
  • of reviews with non-statistical summary 1 (2%)
  • of guidelines with non-statistical summary 1 (2%)
Systematic overview of reviews 1 (2%)
  • with non-statistical summary 1 (2%)

*Percentages do not sum to 100 as some guidelines used more than one approach.