Table 1. Comparison of three different BLAST tools that explicitly deal with e-value statistics correction.

iBLAST supports e-value correction across time and space without requiring prior knowledge of the entire database while the other tools can perform e-value correction in limited scenarios.

Feature	mpiBLAST	NOBLAST	iBLAST
E-value correction for Karlin-Altschul statistics	✔	✔	✔
E-value correction for Spouge statistics	✘	✘	✔
Aggregate search results against pre-planned database segments	✔	✔	✔
Aggregate search results against arbitrary database instances	✘	✘	✔
Reuse existing search results	✘	✘	✔