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. 2021 Apr 22;16(4):e0248429. doi: 10.1371/journal.pone.0248429

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© 2021 Chi et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) SNP rs9275224 is a meQTL associated with average M-value of the DMR at genetic positions 32,810,706–32,810,742 (GRCh37) on chromosome 6. See S3 Table for the remaining meQTL-DMR pairs. (B) Density plot of associated and unassociated SNP-DMR pairs by absolute distance. The significance criteria for association is having a Benjamini-Hochberg adjusted p-value (p) ≤ 0.05. While distance is approximately uniformly distributed for unassociated SNP-DMR pairs, the distances of associated SNP-DMR pairs is concentrated around 153 kb. (C) MHC region spanning the HLA-DQA1, HLA-DQB1, and HLA-DQA2 loci with high density of the meQTL-DMR pairs. Each DMR is specified by its chromosome, starting position, and ending position, in GRCh37 genetic coordinates.