Table 6. Multivariate logistic regression of SS status against MHC meQTLs.
| SNP rs ID | CHR | genetic position | p-value | OR (95% CI) |
|---|---|---|---|---|
| rs2734985 | 6 | 29818662 | 0.505 | 0.952 (0.823–1.101) |
| rs2261033 | 6 | 31603591 | 0.072 | 0.875 (0.756–1.010) |
| rs3021302 | 6 | 32623150 | 0.000 | 1.688 (1.413–2.015) |
| rs9275224 | 6 | 32659878 | 0.014 | 1.257 (1.048–1.509) |
| rs9275374 | 6 | 32668526 | 0.519 | 1.066 (0.878–1.294) |
| rs2858332 | 6 | 32681161 | 0.002 | 1.304 (1.102–1.544) |
Multivariate logistic regression of SS case status again all MHC MeQTLs supporting the causal mediation model based on genotypes from previous European GWAS [7]. The logistic regression adjusted for European ancestry, sex, and smoking status, following Taylor et al. [7], and SS case status was determined based on the 2016 ACR/EULAR classification criteria [32]. CHR = chromosome; OR = odds ratio; CI = confidence interval.