Figure 5. Differential ODP expression by human gut microbes in healthy and disease states.

(A) Detection of microbial OXC and FRC in the subject-matched metagenome and metatranscriptome from healthy subjects, UC, CD, or CD-L3 patients. For each species shown, the subjects are divided into one of four categories based on the co-detection of ODE in the matched metagenome and metatranscriptome. (B) Expression of microbial FRC and OXC in the metatranscriptomes of healthy subjects, UC, CD, or CD-L3 patients. Boxplot reflects the subjects, in whose metatranscriptome the corresponding enzyme is detected. *p<0.01, **<0.0001 by multiple-adjusted Mann–Whitney tests.