Table 6.
Authors | Journal and Year | Study Design | Study Group (Total No.) | Surgery Type | Administration Mode, Time, and Dosage | Main Clinical Outcome | Main Results | Complications Related to TXA |
---|---|---|---|---|---|---|---|---|
Jennes et al | J Burn Care Rehabil 2003 | Preliminary RCT | 14 patients (27) | Tangential burn excision | 20 mg/kg EV preoperative | Intraoperative and postoperative bleeding in 24 h | TXA group showed a reduction in blood loss dependent on the calculation method employed | None |
Tang et al | Journal of Plastic, Reconstructive & Aesthetic Surgery 2012 | Case report | 30 patients | Burns debridement and grafting | Dressing gauze soaked in 500 mg/mL of TXA diluted in 100 mL of 0.9% saline applied to the bleeding area for 5–10 min | None | None | None |
Dominguez et al | Minerva Anestesiologica 2017 | RC | 52 patients (107) | Primary burn wound excision and grafting | EV at a loading dose of 10 mg/kg over 5 min, followed by continuous infusion of 1 mg/kg/h | Incidence of allogeneic transfusion and in the number of pRCB required | ARR of 28.7% in the intraoperative and 24.2% in the postoperative need for transfusionSignificant reduction in the number of pRBC and volume (P = 0.018)Reduction in the incidence of regrafting needed (P = 0.034) | None |
ARR, absolute risk reduction; N/A, not available; pRBC, packed red blood cell transfusion, RC, retrospective cohort.