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. 2021 Mar 23;9(3):e3172. doi: 10.1097/GOX.0000000000003172

Table 6.

TXA in Burn Surgery

Authors Journal and Year Study Design Study Group (Total No.) Surgery Type Administration Mode, Time, and Dosage Main Clinical Outcome Main Results Complications Related to TXA
Jennes et al J Burn Care Rehabil 2003 Preliminary RCT 14 patients (27) Tangential burn excision 20 mg/kg EV preoperative Intraoperative and postoperative bleeding in 24 h TXA group showed a reduction in blood loss dependent on the calculation method employed None
Tang et al Journal of Plastic, Reconstructive & Aesthetic Surgery 2012 Case report 30 patients Burns debridement and grafting Dressing gauze soaked in 500 mg/mL of TXA diluted in 100 mL of 0.9% saline applied to the bleeding area for 5–10 min None None None
Dominguez et al Minerva Anestesiologica 2017 RC 52 patients (107) Primary burn wound excision and grafting EV at a loading dose of 10 mg/kg over 5 min, followed by continuous infusion of 1 mg/kg/h Incidence of allogeneic transfusion and in the number of pRCB required ARR of 28.7% in the intraoperative and 24.2% in the postoperative need for transfusionSignificant reduction in the number of pRBC and volume (P = 0.018)Reduction in the incidence of regrafting needed (P = 0.034) None

ARR, absolute risk reduction; N/A, not available; pRBC, packed red blood cell transfusion, RC, retrospective cohort.