Table 7.

TXA in Microsurgery

Authors	Journal and Year	Study Design	Study Group (Total No.)	Surgery Type	Administration Mode, Time, and Dosage	Main Clinical Outcome	Main Results	Complications Related to TXA
Valerio et al	Military Medicine 2015	RC	19 patients (173)	100 pedicle, 73 free flaps for extremity reconstruction	IV: Pre operatory IV, dose N/A	Flap success/failure ratesComplicationsRate of VTE	No difference in flap successful rate and complication	None
Lardi et al	Gland Surgery 2018	RC	50 patients (83)	63 free tissue transfer for immediate breast reconstruction	IV: Up to 3 g IV according to intra- and postoperative blood loss	Postoperative complications and blood loss during the first 24 h	Intraoperative and blood loss during the first 24 h was reduced significantly (P < 0.001) with the use of TXATXA did not increase the risk of thrombosis	None

N/A, not available; RC: Retrospective Cohort; VTF, venous thromboembolic events.