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Hypothesized mechanisms of the role of Rap1GAP in Ang II-induced cardiomyocyte hypertrophy. Rap1GAP inhibits autophagy by suppressing the AMPK/AKT/mTOR signaling pathway and increases ROS production in Ang II-induced hypertrophic cardiomyocytes. Inhibition of autophagy reduces ROS clearance and further aggravates cardiac injury.
