Table 2.
Liver enzyme and cardiac function parameters stratified by serum ferritin level classification.
| Serum ferritin (ng/mL) | ||||
|---|---|---|---|---|
| <2500 (n = 22) | 2500–5000 (n = 20) | >5000 (n = 24) | p value | |
| Liver enzymes, ng/mL (mean ± SD) | ||||
| AST | 44.8 ± 21.9 | 54.6 ± 2.0 | 65.3 ± 35.9 | 0.066 |
| ALT | 37.5 ± 19.3 | 50.5 ± 25.5 | 60.9 ± 43.6∗ | 0.051 |
| Cardiac function parameters (mean ± SD) | ||||
| Echocardiography | ||||
| LVPWDD (mm) | 9.0 ± 1.9 | 8.8 ± 1.5 | 7.7 ± 1.1∗ | 0.017 |
| LVPWSD (mm) | 13.6 ± 1.8 | 14.8 ± 4.5 | 13.5 ± 2.7 | 0.312 |
| LVEDV (mL) | 145.5 ± 14.3 | 96.0 ± 21.5 | 88.8 ± 19.0 | 0.066 |
| LVESV (mL) | 36.8 ± 11.5 | 32.8 ± 9.7 | 31.5 ± 10.7 | 0.221 |
| LVSV (mL) | 66.4 ± 14.2 | 63.1 ± 13.3 | 57.3 ± 10.2∗ | 0.054 |
| LVEF (%) | 64.7 ± 4.8 | 66.3 ± 4.5 | 65.2 ± 5.2 | 0.552 |
| LVFS (%) | 35.4 ± 3.9 | 36.6 ± 3.3 | 35.6 ± 3.9 | 0.580 |
| LV diastolic function E/A ratio (m/s) | 1.6 ± 0.4 | 1.6 ± 0.3 | 1.6 ± 0.3 | 0.886 |
| LV diastolic function DT (ms) | 168.0 ± 43.3 | 155.5 ± 27.2 | 154.0 ± 25.6 | 0.304 |
| LV diastolic function E/E′ | 9.7 ± 2.7 | 13.5 ± 18.5 | 12.4 ± 13.1 | 0.636 |
| LV diastolic function IVRT (ms) | 70.5 ± 8.9 | 71.3 ± 5.1 | 64.5 ± 17.2 | 0.262 |
| LV diastolic function LAVI (mL/m2) | 33.9 ± 17.3 | 28.2 ± 5.4 | 27.3 ± 6.8 | 0.130 |
| Mean PA pressure (mmHg) | 18.6 ± 10.1 | 18.6 ± 8.3 | 20.2 ± 8.5 | 0.799 |
| TAPSE (mm) | 24.0 ± 3.8 | 23.4 ± 2.8 | 21.1 ± 2.9∗ | 0.011 |
| Electrocardiography, n (%) | 0.958 | |||
| Normal | 11 (52.4) | 8 (44.4) | 10 (41.7) | |
| Tachycardia | 2 (9.5) | 0 (0.0) | 4 (16.7) | |
| T-wave inversion | 3 (14.3) | 10 (55.6) | 7 (29.2) | |
| Left ventricular hypertrophy | 2 (9.5) | 0 (0.0) | 2 (8.3) | |
| RBBB | 2 (9.5) | 0 (0.0) | 0 (0.0) | |
| Arrhythmia | 1 (4.8) | 0 (0.0) | 0 (0.0) | |
| Supraventricular extra systole | 0 (0.0) | 0 (0.0) | 1 (4.2) | |
∗ p < 0.05 compared with serum ferritin <2500, AST: aspartate aminotransferase; ALT: alanine aminotransferase; LVPWDD: left ventricular posterior wall diastolic diameter; LVPWSD: left ventricular posterior wall systolic diameter; LVEDV: left ventricular end-diastolic volume; LVESV: left ventricular end-systolic volume; LVSV: left ventricular stroke volume; LVEF: left ventricular ejection fraction; LVFS: left ventricular fractional shortening; LV: left ventricle; DT: deceleration time; IVRT: isovolumic (or isovolumetric) relaxation time; LAVI: left atrial volume index; PA: pulmonary artery; TAPSE: tricuspid annular plane systolic excursion; RBBB: right bundle branch block.