Fig. 2.

Genome structure, coding proteins, and viral particle structure diagram of coronavirus represented by SARS-CoV-2. a Genome structure, functional domains and locations of SARS-CoV-2. NSP, nonstructural proteins; 3Clpro, 3C-like protease; NiRAN, nidovirus RdRp-associated nucleotidyltransferase; RdRp, RNA-directed RNA polymerase; ZBD, Zn-binding domain covalently linked to HEL1; HEL1, helicase of superfamily 1; NendoU, endonuclease; 2′-O-MT, 2′-O-methyltransferase; ExoN, 3′-5′ exonuclease; SUD-M, SARS-unique domains; ADRP, ADP-ribose-1″-phosphatase; PLpro, papain-like protease; NAR, nucleic acid-binding domain. b Viral particle diagram of SARS-CoV-2. Structural proteins of S, N, M, and E are labeled, and the red line indicates the RNA genome