Table 1.
Phosphatidylcholine hydroperoxide (PCOOH) and phosphatidylethanolamine hydroperoxide (PEOOH) concentrations in microsomes and plasma membranes of rat hepatocytes
Age (months) | PCOOH (pmol/mg protein) | PEOOH (pmol/mg protein) | PCOOH + PEOOH (pmol/mg protein) | |
---|---|---|---|---|
Microsomes | 2 (n = 5) | 12 ± 5 | 6 ± 3 | 17 ± 8 |
17 (n = 9) | 34 ± 14* | 12 ± 5** | 46 ± 18* | |
Plasma membranes | 2 (n = 5) | 23 ± 4 | 9 ± 2 | 31 ± 5 |
17 (n = 9) | 225 ± 96*** | 81 ± 31*** | 306 ± 126*** |
Values represent mean ± SD. Figures in parenthesis show the number of rats examined.
*P < 0.01, compared with PCOOH or PCOOH + PEOOH in the 2-month-old group; **P < 0.05, compared with PEOOH in the 2-month-old group; ***P < 0.001, compared with the respective hydroperoxide in the 2-month-old group.
Adapted with permission from Ref. 47. Copyright 1998 Elsevier.