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. 2021 Mar 19;40(16):2858–2871. doi: 10.1038/s41388-021-01729-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b TMCC3 silenced AS-B145, AS-B634, and their control cells were implanted into mammary fat pad of NSG female mice and tumor sizes were monitored weekly. The photographs (a) and weights (b) of tumors from control (shControl) and TMCC3 silenced (shTMCC3) AS-B145 and AS-B634. c, d Tumor growth curves of control and TMCC3 silenced AS-B145 and AS-B634. Data represent mean ± SD (n = 5, AS-B145 and n = 8, AS-B634). e, f Tumor growth curve of TMCC3-overexpressed and vector transduced MCF7. g Effects of TMCC3 silencing on breast cancer stem cell population (H2k^d−CD24⁻CD44⁺) of AS-B145 PDX tumor as determined by flow cytometry. h The expression of Ki67 in shControl and shTMCC3 transduced AS-B634 PDX tumors (n = 3). Scale bar = 100 μm. **p < 0.01, ^##p < 0.0001.