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. 2021 Mar 19;40(16):2872–2883. doi: 10.1038/s41388-021-01720-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — MTT assay of epirubicin dose response following pre-treatment of MDA.MB.468 and MDA.MB.231 cell lines with low, medium, and high doses of LXR agonists (A) or antagonist (B). Data shown are mean with SEM of three independent replicates each performed with six technical replicates. Statistical significance was determined using non-linear regression curve comparison against epirubicin (EPI) only curve. Colony Forming Assays measuring how the ability of MDA.MB.468 and MDA.MB.231 cell lines to generate colonies after epirubicin exposure is improved by pre-treating cells with LXR agonists (C) or antagonist (D). Three or four independent replicates were performed (as indicated), each independent replicate is the mean of three technical repeats. p values were calculated using paired t test.