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. 2021 Mar 19;40(16):2898–2909. doi: 10.1038/s41388-021-01743-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Volcano plot of differentially expressed lncRNAs between tumor and normal samples in TCGA. The lncRNAs that were significantly upregulated in L3 and L1 were highlighted and colored purple and yellow, respectively. The lncRNAs that were upregulated in tumors and correlated with unfavorable prognosis were enlarged, with dot size proportional to −log10(P-value) of Cox regression test. B Expression of H19 was associated with unfavorable prognosis in the TCGA cohort. C–E Expression of LINC01614 was associated with unfavorable prognosis in the TCGA (C), ACRG (D), and Singapore cohort (E). The cut-off for defining the high expression group and low expression group were selected to maximize the survival difference (with the minimum P-value by log-rank test (P_log-rank) of all cut-off values tested). P_cox was calculated by the Cox regression test.