Table 2. Relationships between cardiovascular proteins and intima-media thickness of the common carotid artery (IMT-CCA).
Sixty-three proteins were identified in the discovery phase and were evaluated in the validation step. This table only show the 21 proteins with FDR<5% in the validation meta-analysis following adjustment for age and sex. Also data following further adjustment for cardiovascular (CV) risk factors are shown. We demanded the multiple-adjusted p-value to be <0.05 in order to claim that the relationship between a protein and an outcome was significant.
| Age and sex-adjusted | Adjusted for CV risk factors | |||||
|---|---|---|---|---|---|---|
| Protein | Beta | SE | p-value | Beta | SE | p-value |
| C-X-C motif chemokine 6 (CXCL6) | .019 | .00096 | 2.46e-27 | −.00137 | .00096 | .15 |
| Matrix metalloproteinase-12 (MMP-12) | .0086 | .00096 | 4.75e-19 | .0064 | .00096 | 2.19e-11 |
| Galanin peptides (GAL) | −.0066 | .00096 | 5.89e-12 | −.0043 | .00096 | 5.68e-06 |
| T-cell immunoglobulin and mucin domain 1 (TIM-1) | .0038 | .00096 | .000056 | .0015 | .00096 | .10 |
| N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) | .0038 | .00096 | .00008 | .0026 | .00095 | .0053 |
| CD40L receptor (CD40) | −.0037 | .00096 | .00010 | −.0038 | .00096 | .000058 |
| Monocyte chemotactic protein 1 (MCP-1) | −.0036 | .00096 | .00016 | −.0040 | .0017 | .021 |
| Caspase-8 (CASP-8) | −.0035 | .00095 | .00018 | −.0036 | .00095 | .00016 |
| Eosinophil cationic protein (ECP) | .0033 | .00096 | .00061 | .0021 | .00096 | .023 |
| Interleukin-6 (IL-6) | .0032 | .00096 | .00074 | .00098 | .00096 | .30 |
| C-X-C motif chemokine 1 (CXCL1) | .0030 | .00096 | .0014 | .0012 | .00096 | .18 |
| Growth/differentiation factor 15 (GDF-15) | .0030 | .00097 | .0015 | .000022 | .00097 | .98 |
| Stem cell factor (SCF) | −.0030 | .00096 | .0017 | −.00066 | .00096 | .48 |
| Pappalysin-1 (PAPPA) | −.0030 | .00097 | .0017 | −.0029 | .00097 | .0025 |
| Myeloperoxidase (MPO) | .0028 | .00096 | .0035 | .00092 | .00096 | .33 |
| CD40 ligand (CD40L) | −.0026 | .00096 | .0054 | −.0037 | .00095 | .000073 |
| Osteoprotegerin (OPG) | .00269 | .00097 | .0054 | .0015 | .00097 | .10 |
| Heat shock 27 kDa protein (HSP 27) | −.0024 | .00095 | .0090 | −.0037 | .00095 | .000086 |
| Matrix metalloproteinase-7 (MMP-7) | .0024 | .00095 | .010 | .0010 | .00095 | .25 |
| Thrombomodulin (TM) | −.0023 | .00096 | .015 | −.0033 | .00096 | .00047 |
| Follistatin (FS) | .0023 | .00096 | .015 | −.00083 | .00096 | .38 |