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. 2021 Apr 22;11:8786. doi: 10.1038/s41598-021-87710-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma proteins differing between healthy controls and CKD. (a) illustrates the proteins found to be significantly different in the plasma of the stage 3 or 4 CKD patients as compared to the healthy controls. (b) shows the proteins found to be significantly different between the post-transplant patients with stage 3 or 4 CKD as compared to the healthy controls. Considering the large number of proteins detected by this assay, we only included those with any differences between the CKD subjects and the post-transplant subjects as compared to the healthy controls. The heat map was created via Morpheus, https://software.broadinstitute.org/morpheus. ABV: CKD: chronic kidney disease, Transplant: post-transplant CKD, YKL-40: also chitinase-3-like protein 1 (CHI3L1), IgA: immunoglobulin A, Mcl-1: Myeloid Cell Leukemia Sequence 1, CXCL16: Chemokine (C-X-C motif) ligand 16, suPAR: soluble urokinase plasminogen activator receptor, EFN: ephrin, SOST: sclerostin, S100A4: S100 calcium-binding protein A4, RSPO3: R-Spondin 3, VEGF: vascular endothelial growth factor, REG4: regenerating islet-derived protein 4, FABPL: fatty acid-binding protein, liver-type, TIMP-1: tissue inhibitor of metalloproteinases, IGFBP: insulin-like growth factor-binding protein, PIANP: PILR Alpha Associated Neural Protein, SECTM1: secreted and transmembrane protein 1, Ephrin: Eph family receptor interacting proteins, DSC: desmocollin, SMOC1: secreted modular calcium-binding protein 1, PSP: phosphoserine phosphatase, MIA: melanoma inhibitory activity, FLRT: Fibronectin leucine-rich repeat transmembrane protein, NEGR: neuronal growth regulator, C1QR1: complement component C1q receptor, LTBP: latent-transforming growth factor beta-binding protein, FSTL: Follistatin-related protein, FAM3D: family with sequence similarity 3 member D, tPA: tissue plasminogen activator, C5: complement 5, SAP: SLAM-associated protein, IL-13Ra1: interleukin 13 Receptor Subunit α 1, BCMA: B cell maturation antigen, IL-23: interleukin-23, G-CSF-R: granulocyte colony-stimulating factor receptor, MCP-1: monocyte chemoattractant protein-1, ZNRF3: Zinc And Ring Finger 3, LPPL: lysophospholipase, 6Ckine/ CCL21: chemokine ligand 21, GFRa: GDNF family receptor α, EMAP: echinoderm microtubule-associated protein, HIF-1α: hypoxia-inducible factor- 1α, GPDA: glyceraldehyde-3-phosphate dehydrogenase, IL-10 Ra: interleukin-10 Rα, LRRK-2: dardarin, HMG: high mobility protein, CHKB: choline kinase beta, OPN: osteopontin, ApoM: apolipoprotein- M, ERBB1: erythroblastosis oncogene B-1, SCFsR: Stem Cell Factor Soluble Receptor, TECK/ CCL25: chemokine ligand 25.