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. 2021 Apr 22;11:8786. doi: 10.1038/s41598-021-87710-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

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Proteins differing between healthy controls and patients with chronic kidney disease. A VENN diagram is shown for the proteins found to be significantly higher or lower in the plasma of CKD patients and the post-transplant CKD patients (each group compared to the plasma proteins of the healthy controls). Of those proteins, 44 were found to be shared as they were significantly higher in both the CKD patients and the post-transplant CKD patients. The red font was used to the proteins that were higher in CKD or in post-transplant CKD (vs. healthy). The blue font was used to denote the proteins that were lower in CKD or post-transplant CKD (vs. healthy controls). ABV: YKL-40: also chitinase-3-like protein 1 (CHI3L1), IgA: immunoglobulin A, Mcl-1: Myeloid Cell Leukemia Sequence 1, CXCL16: Chemokine (C-X-C motif) ligand 16, suPAR: soluble urokinase plasminogen activator receptor, EFN: ephrin, SOST: sclerostin, S100A4: S100 calcium-binding protein A4, RSPO3: R-Spondin 3, VEGF: vascular endothelial growth factor, REG4: regenerating islet-derived protein 4, FABPL: fatty acid-binding protein, liver-type, TIMP-1: tissue inhibitor of metalloproteinases, IGFBP: insulin-like growth factor-binding protein, PIANP: PILR Alpha Associated Neural Protein, SECTM1: secreted and transmembrane protein 1, Ephrin: Eph family receptor interacting proteins, DSC: desmocollin, SMOC1: secreted modular calcium-binding protein 1, PSP: phosphoserine phosphatase, MIA: melanoma inhibitory activity, FLRT: Fibronectin leucine-rich repeat transmembrane protein, NEGR: neuronal growth regulator, C1QR1: complement component C1q receptor, LTBP: latent-transforming growth factor beta-binding protein, FSTL: Follistatin-related protein, FAM3D: family with sequence similarity 3 member D, tPA: tissue plasminogen activator, C5: complement 5, SAP: SLAM-associated protein, IL-13Ra1: interleukin 13 Receptor Subunit α 1, BCMA: B cell maturation antigen, IL-23: interleukin-23, G-CSF-R: granulocyte colony-stimulating factor receptor, MCP-1: monocyte chemoattractant protein-1, ZNRF3: Zinc And Ring Finger 3, LPPL: lysophospholipase, 6Ckine/ CCL21: chemokine ligand 21, GFRa: GDNF family receptor α, EMAP: echinoderm microtubule-associated protein, HIF-1α: hypoxia-inducible factor- 1α, GPDA: glyceraldehyde-3-phosphate dehydrogenase, IL-10 Ra: interleukin-10 Rα, LRRK-2: dardarin, HMG: high mobility protein, CHKB: choline kinase beta, OPN: osteopontin, ApoM: apolipoprotein- M, ERBB1: erythroblastosis oncogene B-1, SCFsR: Stem Cell Factor Soluble Receptor, TECK/ CCL25: chemokine ligand 25.