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. 2021 Apr 22;11:8786. doi: 10.1038/s41598-021-87710-0

Figure 3.

Figure 3

Comparison of the plasma and extracellular vesicle proteomes. The heatmap indicates that the proteins detected in the plasma differed significantly from the proteins identified by evaluating the circulating EVs. This observation was independent of the study group. The heat map was created via Morpheus, https://software.broadinstitute.org/morpheus. ABV: IL: interleukin, IFN: interferon, STAT: signal transducer and activator of transcription, C1QR1: complement component C1q receptor, CXCL: Chemokine (C-X-C motif) ligand, GP 130: glycoprotein 130, IL-1R AcP: IL-1R accessory protein, 6Ckine/CCL21: chemokine ligand 21, MCP: monocyte chemoattractant protein, TLR: toll-like receptor, IRF1: interferon regulatory factor-1 MIP 3A: macrophage inflammatory protein-3 (also CCL20), TGF-b1: transforming growth factor-β1, MICA:MHC Class I Polypeptide-Related Sequence A, CLF1/CLC complex: cytokine-like factor-1/cardiotrophin-like cytokine, IgA: immunoglobulin A, c4b: complement fragment 4b, c5: complement 5, Factor I: complement factor I, c3b: complement fragment 3b, IgG: immunoglobulin G.