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. 2021 Apr 22;11:8786. doi: 10.1038/s41598-021-87710-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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This illustrates the levels of VEGF-D (a), VEGF-A (b), and CFD (c) in the healthy controls and in the subjects with CKD stage 3b and 4 from the first cohort. Additionally, we show the levels of these proteins in the CKD validation cohort. Notably both VEGF-D and CFD were increased in the 2 CKD cohorts as compared to the healthy controls. VEGF: vascular endothelial growth factor, CFD: complement factor D. The figure was created via Prism 9, https://www.graphpad.com/scientific-software/prism/.